What is CBD? Cannabidiol, also known as CBD, is one of over 60+ naturally occurring cannabinoid compounds found in Cannabis, an annual herbaceous flowering plant. CBD oil is derived from an organic substance formed in the plant’s secretions. Both marijuana and hemp are forms of cannabis. However, cannabis does not mean marijuana. Cannabis is the genus name and general umbrella term, under which all forms of marijuana and hemp fall. Until recently, delta-9 tetrahydrocannabinol, or THC, was the most well-known and studied cannabinoid due to its abundance in marijuana. However, as the second most prevalent cannabinoid in marijuana and the top non-psychoactive cannabinoid found in hemp, CBD has been gaining momentum in the scientific community and media. Unlike THC, CBD does not cause any feeling of “high,” which contributes to its legalization across the United States. CBD does not typically have any immediate noticeable effect, though some customers have reported otherwise when using isolates. Our CBD products and extracts are derived from hemp (not marijuana), and can also be referred to as CBD-rich hemp oil, hemp-derived CBD oil, CBD-rich cannabis oil, or plainly “hemp extracts,” since they typically contain more than just CBD. However, CBD oil is different from hemp seed oil and organic hemp oil, as these are derived from hemp seeds (not the resin) and do not contain cannabidiol. All of Bluebird’s high-CBD hemp crops are grown legally in Colorado, and all products are rigorously tested for safety, quality, and cannabinoid content. How does CBD work? CBD primarily interacts with the body’s endocannabinoid system, a grouping of millions of cannabinoid receptors found throughout your body, but are primarily clustered in the brain and central nervous system. While CBD is a phytocannabinoid, or plant-based cannabinoid, your body also naturally produces cannabinoids, known as endocannabinoids. Almost every organ of your body, including your skin and digestive tract, contains cannabinoid receptors. The endocannabinoid system has four primary purposes including neuroprotection, stress relief, immune response, and regulating the body’s general state of balance, impacting faculties such as appetite, sleep, mood, and pain. Unlike THC, CBD does not interact directly with the two classical cannabinoid receptors (CB1 and CB2). This is why CBD does not cause any psychoactive effect. Instead, CBD inhibits the enzymes that break down endocannabinoids, leading to an increase in your body’s naturally-produced cannabinoids. CBD’s molecular formula is C21H30O2, and it has a molecular mass of 314.4636.

WHAT ARE CANNABINOIDS? Chemical compounds that hold the key to many health benefits. THE ENDOCANNABINOID SYSTEM (ECS) · Present in all humans · Present in all vertebrates and many invertebrates · Receptors exist throughout the body (brain, digestive system, lymphatic system) · Responsible for homeostasis; regulation of breath, inflammation, immune response, mood, pain, GI motility, neuroprotection, hormonal balance, sleep/wake cycle, blood pressure, tumor surveillance, and reproduction · Taught in only 13% of medical, nursing and pharmacy programs · Can be activated by going for a run, i.e. “runner’s high” · May be activated during osteopathic manipulation and acupuncture · Consists of CB1 & CB2 receptors MECHANISMS OF ACTION Cannabidiol (CBD) binds to a G-coupled protein, TRPV-1, which influences inflammation, pain perception and body temperature. Multiple NIH studies show that CBD inhibits FAAH activity, which is responsible for the deterioration of N-arachidonoylethanolamine, commonly known as anandamide. CBD also inhibits anandamide reuptake. The scientists who discovered and isolated the neurotransmitter anandamide discovered that it contributes to elevated mood. Unfortunately, endogenous anandamide levels are very low, and the half-life is rapid. CBD plays an important role by inhibiting anandamide degradation and enhancing endogenous levels. CBG and CBC, other cannabinoids present in Dr. Scott's Hemp, also increase anandamide levels. The other cannabinoid compounds in Dr. Scott's Hemp are valuable on their own, but they also help to realize CBD’s anti-inflammatory, neuroprotective and mood elevating potential by working synergistically, a phenomenon that scientific experts call the “entourage effect.” PRODUCT SAFETY Unlike THC, CBD and other cannabinoids are not psychoactive. Early studies show that even at extremely high doses, CBD remained psycho-tropically inactive. The immunomodulation of cannabinoids has been investigated in human studies to evaluate safety in immunocompromised patients. Evidence supports safety, though there is evidence that CB1 agonists, such as THC, may be maladaptive in liver fibrosis. Dr. Scott's CBD Hemp products contain less than .3% THC. There are no published reports of CBD induced serotonin syndrome, but patients on SSRIs should be cautioned. The American College of Obstetrics and Gynecology recommends pregnant and breastfeeding women not use marijuana, as animal studies revealed potential threats of THC. In vitro and animal studies on CBD and CBN were not associated with negative outcomes. ACOG has not made a recommendation on hemp during pregnancy and breastfeeding, as there is no evidence to support recommending or eliminating it.

What is Full Spectrum ? Our Message: Harnessing the innate power of Mother Nature NATURE IS THE ARCHITECT We believe mother nature provides the best architecture for wellness and healing. In fact, the hemp plant has been used by humans for thousands of years as a herbal remedy to heal a host of ailments. We simply take the best parts of the plant that she has provided us, including the vast array of cannabinoids, terpenes, essential fatty acids, and other phytonutrients, and balance them in simple, easy to use formats. There are at least 113 known cannabinoids produced by the hemp plant. However, today, our pharmaceutical industry is based on a model of developing single molecules against single targets. We are not sure that this is the optimal way to create wellness. We feel the current model is not working. Unfortunately, some of our competitors in the industry borrow from the same playbook and provide products that only contain CBD. We do not believe CBD by itself is the optimal way to consume cannabinoids; our products contain absolutely no isolates or synthetics. Full spectrum hemp oil refers to the pure oil extracted from a hemp plant, containing unmodified cannabinoids and compounds. Unlike isolated or synthetic cannabinoids, full spectrum hemp oil contains an array of cannabinoids, as well as many essential vitamins and minerals, fatty acids, flavonoids and terpenes. These compounds have been proven to work more effectively when presented together in a specifically designed, synergistic manner than when separated into purified molecules. RARE CANNABINOIDS FROM RARE GENETICS We have a feeling there is more to hemp than just CBD and we are passionate about the exploration of other, rare cannabinoids and understanding how they work within the human endocannabinoid system (ECS). In fact, our products contain some of the most diverse cannabinoid profiles on the marketplace — the theory being that all of these molecules interact with the ECS in different ways and to different targets. Our genetic stock enables us to be a leader in the cultivation, extraction, and purification of more exotic cannabinoids. In fact, we’ve already confirmed having varieties extremely high in molecules like THCV, CBC, and CBDV. This is because our cultivars have been gathered from unique places like the Himalayan regions, SE Asia, and Africa. These unique landraces contain more exotic profiles than the traditional cultivars found in Europe, Canada, and even the United States

“The endocannabinoid system is intimately involved in tissue healing in the face of inflammatory conditions, correlating clinically with prevention and treatment of inflammation-mediated pain.” – Fine & Rosenfeld, 2013 THE ENDOCANNABINOID SYSTEM · CB2 receptors are present in the human dorsal root ganglion (DRG) sensory neurons, mediating nociceptive pain2 · Cannabinoid receptor agonists modulate nociceptive thresholds. · CBD is a positive allosteric modulator at α1 and α1 βglycine receptors. · Influences opioid, 5HT3, and N-methyl-d-aspartate receptors responsible for pain modulation · Cannabidiol (CBD) · Not psychoactive THIS LITTLE-KNOWN SYSTEM HELPS MAINTAIN BALANCED, HEALTHY CELLS. Every human possesses an advanced physiological system known as the Endocannabinoid System (ECS). This crucial regulatory system is already making cannabinoid-like structures that foster cellular balance throughout nearly every biological system in your body. MILLIONS OF RECEPTORS Cannabinoid receptors, found on the surface of your cells, are ubiquitous throughout the body and “listen” to the environment around each cell. They transmit information on current conditions to the cell and thereby jump start the proper cellular response, if necessary. Properly functioning receptors have the crucial function of creating Homeostasis in your body’s cells which keeps you healthy and operating at your peak. The most studied are receptors CB1 and CB2, with CB1 most prevalent in the nervous system, and CB2 occurring outside the nervous system, in organs like the stomach, heart and liver. NATURALLY OCCURRING It may come as a surprise that your Endocannabinoid System is already creating cannabinoid-like structures within your body that very closely resemble the cannabinoids in Dr. Scott's Hemp’s products. Endocannabinoids like Anandamide and 2-AG are made when the body senses an imbalance, these molecules are created on-demand to specifically target issues inside your cells that need fixing. This information is presented for educational purposes only. Dr. Scott's Formulators developed this information to provide an understanding of the potential applications of cannabinoids. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Marijuana and hemp are two different varieties of cannabis that come from the same species of plant (Cannabis sativa L). In general, CBD is found abundantly in both. However it’s important to note that CBD is typically found in the seeds and stem of marijuana – not in the flowering buds (which is the part that you smoke). The hemp plant is an entirely different strain of cannabis that contains high quantities of CBD throughout (stem, buds, etc), and practically zero traces of THC. If a hemp plant contains more than 0.3% THC, it is then technically a “marijuana” plant. Most all CBD-based products come from the industrial hemp plant.

Scientifically, industrial Hemp and Marijuana are the same plants, with a genus and species name of Cannabis Sativa. They have a drastically different genetic profile though. Industrial Hemp is always a strain of Cannabis sativa, while marijuana can be Cannabis sativa, Cannabis indica, or Cannabis ruderalis. The major difference is how industrial hemp has been bred compared to a marijuana form of Cannabis sativa. Typically speaking, industrial hemp is very fibrous, with long strong stalks, and barely has any flowering buds, while a marijuana strain of Cannabis sativa will be smaller, bushier, and full of flowering buds. However, newer industrial hemp varieties in the USA are being bred to have more flowers and higher yields of cannabinoids and terpenes, such as our Colorado hemp we’re now using! 99% of the time marijuana has a high amount of THC and only a very low amount of CBD. Hemp, on the other hand, naturally has a very high amount of CBD in most instances and only a trace amount of THC. Fortunately, the cannabinoid profile of hemp is ideal for people looking for benefits from cannabis without the ‘high.’ Hemp is used for making herbal supplements, food, fiber, rope, paper, bricks, oil, natural plastic, and so much more, whereas marijuana is usually used just recreationally, spiritually, and medicinally. The term cannabis oil can refer to either a marijuana or hemp derived oil since marijuana and hemp are two different forms of cannabis. In the USA the legal definition of “industrial hemp,” per Section 7606 of the Agricultural Appropriations Act of 2014, is “INDUSTRIAL HEMP — The term ‘‘industrial hemp’’ means the plant Cannabis sativa L. and any part of such plant, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”

THC affects the brain by binding to naturally-occurring CB-1 receptors in the central nervous system. CBD is a differently-shaped molecule that binds to CB-2 receptors in cell and body tissues outside the central nervous system.

No, CBD will not get you high. Like we just said THC is the molecule that binds to receptors in our brain and is the one responsible for the psychoactive effects of marijuana. In fact, CBD is antagonistic to the marijuana high; it actually prevents THC molecules from binding to the brain’s receptors (hence the reason why it’s often used to subdue the ‘paranoia’ effects of super-potent THC strains).

In states where medical marijuana is legal, any CBD product (whether it comes from hemp or marijuana) is of course perfectly legal. Outside of these legalized states (including shipping from legal to non-legal states), things tend to be a little less clear. According to ProjectCBD.org, “Federal law prohibits U.S. farmers from cultivating hemp as a commercial crop, but the sale of imported, low-THC, industrial hemp products is permitted in the United States.” Technically, this means that as long as the CBD product (oil, vape, topical, etc) is produced from the seeds and stalk of the industrial hemp plant (with less than 0.3% THC), it is permissible to buy, sell, and ship across state lines. (However, in articles like 2014’s Farm Bill, the exact rule seems to be a little less clear). All in all, the fact remains that millions of people buy and use CBD products every day of their lives, and the medication is only getting more popular and widespread with each passing day.

A high-quality CBD product with minimal THC like ours is incredibly unlikely to show up on a drug test. However, low quality CBD products may contain more traces of THC than they claim, in which case it is possible for a screening to pick up on the drug. (Research has shown that people who consume 6 mg of THC per day have a 25% chance of failing a drug test. This translates to about 2,000 mg per day of CBD oil with a THC content of 0.3% or less).

HOW TO GET STARTED Everyone has unique, complex genetic characteristics. Because of these differences, the body’s metabolic response can vary. TINCTURE Each dropper of Spectrum 200 contains 10 mg of active cannabinoids. Each dropper of Spectrum 600 contains 30 mg of active cannabinoids. Day 1: A good starting dose is 15mg active cannabinoids after dinner. If you are taking the Spectrum 200, start with one full dropper. If you are taking the Spectrum 600, start with half a dropper. Monitor how you feel. Day 2: Take the same dosage as day 1 after dinner. Monitor how you feel. Day 3: After a few days, if you feel you need more, you can increase your dose to twice a day. Take your first dose after breakfast and your second dose after dinner. Each individual is different in how their system reacts to these products. It is best to start with a small dose and increase your dose until you achieve the desired results. Try to take each dosage at the same time every day. This will make it easier for you to notice the effects. GEL CAPS Each gelcap contains 15mg of active cannabinoids. Day 1: Take one 15 mg gelcap after dinner. Monitor how you feel. Day 2: Depending on how you feel in the morning you can take a second 15 mg gelcap about 12 hours after your first dose. The most common dosage is 2 gelcaps per day (One in morning, one in the evening) however, start with one to two per day and increase slowly to find the dosage that is right for you. Each individual is different in how their system reacts to these products. It is best to start with a small dose and increase your dose until you achieve the desired results. Try to take each dosage at the same time every day. This will make it easier for you to notice the effects. QUALITY We maintain the highest level of quality control standards to ensure our products contain a consistent level of cannabinoids. We know that people use Dr. Scott's Hemp for many different reasons, we suggest that you take the product and increase the dose until you see the desired effect that works for you. It is very safe to titrate up. Once you reach an effective dosage, you can either maintain that amount or increase it until the desired effect is achieved. If you do not receive additional benefits, reduce your dosage to the original amount.

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COMPLIANCE Setting the standard for compliance in the industry WHY THE 2014 FARM BILL CHANGED EVERYTHING The legal growth and sale of hemp would not be possible without the 2014 Farm Bill. As passed by the House, the bill includes the two-page Section 7606, entitled “Legitimacy of Industrial Hemp Research” provision. This section states that regardless of any other federal law: “the industrial hemp is grown or cultivated for purposes of research conducted under an agricultural pilot program or other agricultural or academic research; and “the growing or cultivating of industrial hemp is allowed under the laws of the State in which such institution of higher education or State department of agriculture is located and such research occurs.” WE ARE COMPLIANT. Working directly with the State of Kentucky, which legalized the commercial growing of industrial hemp, at Dr. Scott's Hemp our formulators are compliant with all existing laws in relation to hemp extracts and byproducts. Section 7606 of the federal law states that regardless of any other federal law (including the Controlled Substances Act), if the growing and cultivation of industrial hemp is allowed under the state laws and overseen by the State Department of Agriculture, then the product can be manufactured and sold as part of the state’s approved hemp pilot program.